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MSF Treats Myanmar Retinitis Patients Using Oral Drugs

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19 October 2018 19:42 WIB

n MSF doctor begins the process for the CMV injection in Myanmar. Now, the uncomfortable process has been replaced with more effective pills and MSF has started providing these pills for its patients in Dawei clinic. Eddy McCall/MFS

TEMPO.CO, Jakarta - During the 20th International AIDS Conference in Melbourne, Australia, Medecins Sans Frontieres (MSF) announced that for the first time in Myanmar, patients have begun receiving oral treatment for Cytomegalovirus (CMV) retinitis, a neglected opportunistic disease linked to HIV/AIDS which can cause permanent blindness. Although this drug has been available since 2001 in the developed world, the only treatment option available in Myanmar until now was once-weekly injections directly into the eye, an extremely uncomfortable procedure for the patient that requires carefully trained doctors.

Following years-long price negotiations with the drug company, Roche, MSF is now providing its patients in Dawei, southern Myanmar, with valganciclovir, a simple pill to be taken daily for up to six months. This is the first time MSF has been able to use this pill in any of its HIV/AIDS projects around the world. All of MSF’s patients diagnosed with CMV retinitis in Myanmar will be receiving valganciclovir by 2015.

While MSF welcomes this breakthrough, the organisation is urging that the price of valganciclovir is reduced further, particularly through generic competition from other drug manufacturers.

"Although this is a very positive step – bringing relief to patients and making treatment of the disease easier for medical care providers – much more still needs to be done to bring prices down and expand access to this crucial medicine," says Dr Jennifer Cohn, medical director of MSF's Access Campaign. "The current negotiated price with Roche is approximately US$280 for a bottle of 60 tablets, and up to US$1,960 per patient for a 27-week course of treatment. This is clearly still far out of reach for many patients in CMV-endemic countries."

Before the advent of antiretroviral treatment for HIV/AIDS in developed countries, CMV retinitis affected roughly one-third of those living with AIDS. Now, the condition is rarely seen in HIV/AIDS patients in Europe or the US. For those who do fall victim to CMV retinitis in wealthier countries, valganciclovir has long been the standard treatment and is proven to be more effective than the injection method.

However, rates of the disease are still high in several developing regions of the world due to poorer screening for HIV and later access to antiretroviral treatment. In Myanmar, rates of the disease among severely ill HIV/AIDS patients are as high as 25 percent.

Ma Khin Khin is a mother of four diagnosed with HIV and CMV retinitis in February this year. She was the very first patient in Myanmar to receive the oral drug. "I didn't feel any side effects and I am feeling better now," said Ma Khin Khin. "Before it was not like that, and I had to lie down all the time. But now I can go everywhere by myself. I have even got my vision back and can read the text messages on my mobile phone."

"We have the medicine to dramatically reduce the suffering and blindness caused by this disease in resource-poor high-HIV burden countries all over the world," says Marcelo Fernandez, MSF medical coordinator. "The current inhumane and difficult-to-access treatment is not acceptable in rich countries; we should act now to make it a thing of the past in resource-poor countries as well."

CMV retinitis treatment is still absent from current and pending World Health Organization (WHO) guidelines for the management of HIV in resource-limited settings. MSF is urging WHO to amend these guidelines and encourage their adoption into national treatment protocols.

MEDECINS SAND FRONTIERES (MYANMAR)



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